Consistent with the development of pathological LVH, TAC was associated with increased cardiac fibrosis (P < 0.001; Extended Data Table 1 and Extended Data Fig. 1b) and enhanced collagen III (Col3a1) expression (P < 0.001; Extended Data Table 1) in both WTLs and Piezo1P1-tdT/P1-tdT mice. This evidence concerns the gene COL3A1 and fibrosis.