Echocardiographic indices of LVH—LV wall thickness to chamber radius ratio (h/r) and LV mass—increased significantly (both P < 0.001) after TAC in both α-MHC-MCM+/− mice and P1fl/flMCM+/− control mice (Fig. 2e,f), but these changes were absent in Piezo1 KO mice after TAC (Fig. 2e,f). Here, PIEZO1 is linked to persistent truncus arteriosus.