Regarding the gene expression profiles of immunological and antioxidant markers in the buffaloes, the expression levels of the following genes were significantly higher in the buffaloes affected by endometritis than in the resistant ones: A2M, ADAMTS20, KCNT2, MAP3K4, MAPK14, FKBP5, FCAMR, TLR2, IRAK3, CCl2, EPHA4, and iNOS. This evidence concerns the gene A2M and endometritis.