Regarding the gene expression profiles of immunological and antioxidant markers in the buffaloes, the expression levels of the following genes were significantly higher in the buffaloes affected by endometritis than in the resistant ones: A2M, ADAMTS20, KCNT2, MAP3K4, MAPK14, FKBP5, FCAMR, TLR2, IRAK3, CCl2, EPHA4, and iNOS. The gene discussed is KCNT2; the disease is endometritis.