The previously described factors may be responsible for the notable change in the expression patterns of the antioxidant (SOD, CAT, NDUFS6, Nrf2, Keap1, PRDX2, HMOX1, OXSR1, ST1P1, and SERP1) and immunological (TLR4, IL-8, IL-17, NFKB, SLCA11A1, and NCF4) indicators in the buffaloes with endometritis. The gene discussed is SERP1; the disease is endometritis.