Another study also showed that SHBG inhibits inflammation and lipid accumulation in macrophages and adipocytes, and the addition of testosterone or estradiol does not alter these effects of SHBG [51], which may suggest that high SHBG reduces the risk of glycemic disorder caused by glyphosate by inhibiting obesity-associated inflammation. This evidence concerns the gene SHBG and obesity due to melanocortin 4 receptor deficiency.