To further explore the potential implication and functional role of METTL3 on SNHG7 in MNNG-induced GC, herein, we first knocked down the METTL3 expression in MNNG-induced 40-generation malignantly transformed Ges-1 cells (MC-40) and AGS GC cells by shRNA. Here, METTL3 is linked to gastric cancer.