One such circRNA, circMcph1, exacerbates liver fibrosis through a similar mechanism by acting as a sponge for miR-370-3p, thereby increasing interleukin-1 receptor-associated kinase 2 (Irak2) expression and intensifying KCs-mediated inflammatory damage and fibrosis through indirect regulation of HSCs [48]. The gene discussed is IRAK2; the disease is Hepatic fibrosis.