Although the relationship between the composition of porcine bile acid and non-fatty porcine liver has not been directly demonstrated by scientific evidence, the HDCA was found to have therapeutic effects on non-alcoholic fatty liver disease (NAFLD) in multiple mouse models [40] by inhibiting RAN-mediated PPARα nucleus–cytoplasm shuttling [41]. The gene discussed is PPARA; the disease is metabolic dysfunction-associated steatotic liver disease.