The pituitary adenylate cyclase-activating polypeptide (PACAP)-selective PAC1 receptor (PAC1R) is a member of the vasoactive intestinal peptide (VIP)/secretin/glucagon family of G protein-coupled receptors (GPCRs) [45], which play important roles in metabolic disorders. The gene discussed is ADCYAP1; the disease is Other metabolic disease.