Alternatively, cancer cells also cope with ROS by increasing NRF2 signaling and antioxidant enzyme expression (enzymes involved in GSH synthesis, thioredoxin, thioredoxin reductase, sulfiredoxin, peroxiredoxin, GPx, glutathione S-transferases, catalase (CAT) and superoxide dismutase (SOD)) [6,9,10]. The gene discussed is CAT; the disease is cancer.