CD8A and cancer: A phase 2 non-randomized study that included multiple types of cancer patients on FMD demonstrated that this dietary intervention could reduce monocytic myeloid-derived suppressor cells CD14+HLA-DR- and CD14+PD-LD+, both reported as highly suppressive subsets, while upregulating CD8+PD-1+CD69+-activated T cells, cytolytic natural killer (NK) cells, and CD3+CD25+ T cells, all reported as anti-tumor effectors [80].