INS and Insulin resistance: This dose-dependent phenomenon, i.e., a stronger incremental insulin response than glucose response, with increasing doses of rapidly acting carbohydrates in people with relatively intact physiology has also previously been observed [28] and has been ascribed in HV to mechanisms like reduced clearance of endogenous insulin with increasing glucose load of rapidly available carbohydrates [29,30,31], or induction of acute insulin resistance [30].