When exposed to stressful stimuli, such as IL-6 and TNF, triggered by a disease such as stroke, the HPA axis is activated, leading to the production of glucocorticoids or cortisol, the primary stress hormones, which exert an anti-inflammatory and immunosuppressive effect on pathological tissue, along with a negative feedback on the hypothalamus and pituitary glands to control the response [92]. Here, TNF is linked to Stroke.