In IPA groups, immune function in MCAO mice was modulated, as proved by the reversing trend of the increased Th17 (CD4+ IL17+) and reduced Treg (CD4+ CD25+ Foxp3+) numbers in the GALT, such as PPs and MLNs, as well as decreasing CD3+ cells and increasing Tregs in the ipsilesional injured brain parenchyma, which further alleviated the neuroinflammation after stroke, with significantly decreased IL1β, IL6, and CCL2 and increased IL10 at both the mRNA and protein levels. Here, CD4 is linked to stroke disorder.