Among them, the oyster peptide sequences SSGPIPTTPPPPPPVPK and LRGFGNPPT exhibited a lower binding affinity (−9 kcal/mol and −8.9 kcal/mol, respectively) with DPP-IV compared to the positive control Linagliptin (−8.7 kcal/mol), indicating that they had more stable binding conformations with DPP-IV and showed a good potential for anti-T2D activity. The gene discussed is DPP4; the disease is type 2 diabetes mellitus.