The maximum inhibition rates of CRP-1, CRP-2, CRP-3, and CRP-4 on colon cancer HCT-116 cells were 34.31 ± 0.83%, 36.65 ± 0.31%, 36.65 ± 0.31%, and 40.44 ± 1.44%, respectively, with CRP-4 showing the highest inhibition rate. The gene discussed is CRP; the disease is malignant colon neoplasm.