Lee et al. identified upregulated expression levels of ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) and chromogranin-A (CHGA) in the primary tumor tissue of LN metastatic CRC patients using iTRAQ-based proteomic analysis and explored its role in invasion, migration and reactive oxygen species generation in cell lines [51]. This evidence concerns the gene CHGA and neoplasm.