In the pancreatic cancer microenvironment, various factors, such as CSF-1, IL-4, IL-13, TGFβ and IL-10, promote myeloid progenitor cell differentiation into monocytes and macrophages [89,90], which in turn secrete immunosuppressive cytokines, chemokines and enzymes, such as TGFβ, IL-10, CCL17, and CCL22 [91]. This evidence concerns the gene IL10 and familial pancreatic carcinoma.