Interleukin 8 (IL-8), a strong pro-inflammatory cytokine, could serve as a good marker in predicting the prognosis of patients [109] and mainly acts as an angiogenic factor, associated with an increased production of VEGF, VEGFR (VEGF receptor) and NRP-2, which are crucial for angiogenesis in growing pancreatic tumor [109]. Here, VEGFA is linked to pancreatic neoplasm.