DCP ratios at weeks 4 and 8 in the non-8W-DC group were also significantly higher than those in the 8W-DC group, suggesting that Dur/Tre treatment, unlike Atz/Bev treatment, does not involve VEGF inhibition and no mechanism may be needed for producing DCP from within the tumor due to hypoxia from inhibited angiogenesis. Here, VEGFA is linked to neoplasm.