In liver fibrosis MCs stimulated to release tryptase and chymase when near nerves lead to fibrogenesis in chronic liver disease [7] The Francis group from Indiana University aimed to further detail the interplay of MC and TGF-β in contributing to liver fibrosis in a MC-deficient model, and while these results were promising, they have recently been called into question by a retraction [26]. This evidence concerns the gene TGFB1 and Hepatic fibrosis.