This figure graphically represents the conclusions of our study, which, through NED evaluation in tumor tissue, we showed that the presence of neuroendocrine clones leads to AR-independent tumor growth and reduced survival in mCRPC patients with NED (red line in Kaplan–Meier survival curve) compared with mCRPC patients without NED (black line in Kaplan–Meier survival curve). Here, AR is linked to neoplasm.