TPX2 and cervical squamous intraepithelial neoplasia: Interestingly, a positive correlation with TP53 mutation was also observed; however, linear regression models, including multiple variables, led the authors to conclude that TPX2 had no significant independent association with CIN; the correlation between high nuclear TPX2 and the expression of the proliferation marker Ki67 rather suggested that TPX2 directly correlates with an increased proliferation status.