WNT5A and melanoma: In these melanoma cells, the use of 1,2- Bis(2-aminophonoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis-(acetoxymethylester) (BAPTA-AM) as a calcium chelator also decreases FLNA cleavage, implying that both ROR2 and calcium are required for Wnt5A-mediated FLNA cleavage, potentially through the activation of calpains [36].