ZSWIM6 and schizophrenia: This single region gained between middle-aged and old-age samples occurred in the first intron of the zinc finger gene Zswim6, which has been previously linked to neurodevelopmental disorders and schizophrenia (Figure 3B and Figure S17) [79,80], and although statistically significant, we noted that the gain appeared to only occur to a noticeable degree in one of the two 24-month samples.