HMOX1 and Alzheimer disease: For instance, higher amounts of ferritin and heme oxygenase-1 (HO-1) were observed in the hippocampus, and cerebral cortex of aged human brains [16], and significant alterations in ferritin heavy and light chains were also detected in brain tissues from Parkinson’s Disease (PD) and Alzheimer’s Disease (AD) patients [17].