ROP is the result of the disruption of retinal vasculature development in a biphasic modality: hyperoxic Phase-1 (Ph1) ROP, which presents retinal microvascular degradation or vaso-obliteration, and hypoxic Phase-2 (Ph2), which results in retinal ischemia triggering an overabundance of vascular endothelial growth factor (VEGF) and insulin growth factor-1 (IGF-1), leading to abnormal intravitreal neovasculature [9]. This evidence concerns the gene VEGFA and retinal ischemia.