SOD1 and malignant colon neoplasm: In addition, different results were obtained by the team of Abd Al Moaty et al. [35], who showed on colon cancer cell lines that thiazolidinediones derivatives cause a decrease in SOD activity in cells of the Caco2 line, which contributes to an increase in ROS production in neoplastic cells and thus may cause death of neoplastic cells [35].