The presence and concentration of proteins such as eosinophilic granule protein-2 (EG-2), granulocyte-macrophage colony-stimulating factor (GM-CSF), tumor necrosis factor-alpha (TNF-α), and interleukin (IL)-8 have been correlated with airway inflammation and asthma severity [15,49,50]. This evidence concerns the gene TNF and asthma.