Another example of miRNAs influencing the TME came from the study of Mei et al. Authors discovered that induction of miRNA-200c is possible by secretion of tumor-derived granulocyte-macrophage colony-stimulating factor (GM-CSF), and miR-200c, in turn, promotes the expansion and immune suppressive activity of MDSCs via targeting PTEN and friend of Gata 2 (FOG2), which can lead to signal transducer and activator of transcription 3 (STAT3) and PI3K/Akt activation [46]. This evidence concerns the gene PTEN and neoplasm.