This nuclear localization of CXCR4 in the liver metastasis tissues from CRC patients was markedly more pronounced than that in cells from normal colorectal tissues, underscoring the critical role of the SDF-1/CXCR4 axis in facilitating the metastasis of CRC to the liver (Figure 6F–H). Here, CXCL12 is linked to colorectal carcinoma.