This enhancement was evidenced by increased levels of SDF-1, CXCR4, and EMT-related proteins, such as Twist-1, Snail, and Vimentin, in the CRC cell lines HT-29 and HCT-116 after exposure to CAF-CM, as shown in Figure 2C,D. Here, CXCL12 is linked to colorectal carcinoma.