However, in CRC tissues with liver metastasis, SDF-1 was predominantly cytoplasmic-stained, whereas CXCR4 was notably nuclear-stained, suggesting a distinct translocation from the cytoplasm to the nucleus, an unusual pathological phenomenon that is usually correlated with aggressive tumor behavior and metastatic potential (Figure 6D,H). Here, CXCR4 is linked to colorectal carcinoma.