Notably, we confirmed that the NF group exhibited a negligible mRNA expression of SDF-1 and CXCR4, which were at minimal to absent levels, as depicted in Figure 2B. There was a substantially higher mRNA and protein expression in CAFs, emphasizing the differential roles of fibroblast subtypes in the tumor microenvironment. The gene discussed is CXCR4; the disease is neoplasm.