Both C5aR1 and C5aR2 (C5L2) receptors are involved in the physio-pathological functions of various ocular diseases, such as retinitis pigmentosa (C5L2) [128], human and experimental cerebral malaria (only C5aR1) [129], or choroidal neovascularization (in mice) [130]. The gene discussed is C5AR1; the disease is cerebral malaria.