Notably, the gnomAD database was recently used to assess the novel pathogenic association of a series of genes, including NSD1, HDAC10, KRT24, ACACA, and TP63, with CRC predisposition [104], while other databases, i.e., ClinVar, HGMD, and InSight, were previously used in a meta-analysis to identify a new pathogenic variant associated with LS in MSH6 exon 4. The gene discussed is MSH6; the disease is Leigh syndrome.