APC and Familial adenomatous polyposis: Based on the annotations recorded in the ClinVar Miner database (https://clinvarminer.genetics.utah.edu/, accessed on 7 April 2024 [28]), out of 10,625 APC variants associated with FAP and AFAP syndromes, 6139 are VUSs (accessed on 7 April 2024) (Table 1).