In a more recent report, a comprehensive meta-analysis based on the use of various computational software tools allowed the authors to identify pathogenic missense variants in 26 genes (ABRAXAS1, ATM, BARD1, BLM, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, EPCAM, MEN1, MLH1, MRE11, MSH2, MSH6, MUTYH, NBN, PALB2, PMS2, PTEN, RAD50, RAD51C, RAD51D, STK11, TP53, and XRCC2) examined in numerous NGS panels to assess the level of hereditary risk in various cancer types, including CRC. Here, MSH2 is linked to colorectal carcinoma.