TGFBI and neoplasm: Beta ig-h3, found with the highest abundance in both regions of the tumor, has been proposed as a marker of metastatic primary colon carcinomas, and its pro-tumorigenic activity was found more relevant in the less severe Dukes stages [81], in accordance with our results highlighting that the beta ig-h3 abundance in the deep tumor was lower in patients with an advanced Dukes stage.