The proteomic study of Torres and coll., investigating the secretion of cancer-associated fibroblasts (CAFs) isolated from the colon tissue of a mouse model, demonstrated that CAFs, which intensely proliferate in the tumor stroma, can release FN, NID-1, collagen alpha2(IV) chain, other ECM components, and ECM-degrading proteases, to support growth, the invasion of the tumor, angiogenesis, and pro-fibrotic processes [37]. This evidence concerns the gene FN1 and cancer.