In the deep region of the tumor, 14-3-3 protein theta and Galphai2 correlated positively with the advancement of the Dukes stage, while beta ig-h3, nuclear autoantigenic sperm protein (NASP), and V-set-immunoglobulin domain-containing protein 2 (VSIG2) exhibited negative correlation. The gene discussed is PROS1; the disease is neoplasm.