In the superficial region of the tumor, significant positive correlations with the worsening of the Dukes stage, from A to C, were observed for alpha-adducin, sorbin-SH3 domain-containing protein 2 (also known as Arg-binding protein 2, ArgBP2), collagen alpha-2(IV) chain, extracellular superoxide dismutase (EC-SOD) and FN, while negative correlations were found for N-WASP and synaptogyrin-2. The gene discussed is SORBS2; the disease is neoplasm.