Bacterial sepsis induces systemic inflammation, which stimulates PCT production in almost all tissues released into the blood stream in response to bacterial endotoxins [55] and inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), interleukin-1-beta (IL-1β), and interleukin-6 (IL-6) [47,56,57,58]. Here, CALCA is linked to bacterial infectious disease with sepsis.