Genetics: It is now clear that there are no KDM1A (lysine demethylase 1A) germline mutations in acromegalic patients, like in gastric inhibitory polypeptide (GIP, alternatively named glucose-dependent insulinotropic polypeptide [10])-dependent primary bilateral macronodular adrenal hyperplasia. Here, GIP is linked to congenital adrenal hyperplasia.