The results of our experiments showed the greatest positive effect on angiogenesis of the cell-mediated delivery of therapeutic transgenes, where the index of the number of CD31+ cells was highest 42 days after ischemia in groups with the combined delivery of genes encoding angiogenic factors (UCBC Ad5-Vegf + Ad5-Ang) or their combination with neurotrophic factor (UCBC Ad5-Vegf + Ad5-Ang + Ad5-Gdnf). The gene discussed is PECAM1; the disease is ischemia.