This study shows that of eight combinations of three transgenes, Vegf, Ang, and Gdnf, injected directly or via human umbilical cord blood mononuclear cells into the region of ischemia, cell-mediated delivery of the combination of Ad5-Vegf, Ad5-Ang, and Ad5-Gdnf stimulates revascularization, reparative myogenesis, and nerve fiber regeneration more effectively up to 42 days after ischemia. Here, GDNF is linked to ischemia.