CTLA4 and lymphoproliferative syndrome: Despite little being known about genetic variants of the CTLA-4 gene in NMSC, it has been established that long-repeat alleles in the (AT)n variants of the CTLA-4 gene have significantly less mRNA expression that could lead to lymphoproliferative disorders that may end up in immune diseases [16], while short-repeat alleles in this gene are associated with higher mRNA stability thus contributing to impaired T-cell activation that may lead to a higher susceptibility to some types of cancer [17].