The results of the analysis of the three genotype models showed no statistically significant association between preeclampsia and maternal ACE rs4646994 polymorphism (additive model, OR 0.81, 95% CI 0.45 to 1.49, I2 = 78%, n = 3; dominant model, OR 0.65, 95% CI 0.28 to 1.54, I2 = 83.4%, n = 3; recessive model, OR 1.02, 95% CI 0.51 to 2.04, I2 = 41.5%, n = 3). The gene discussed is ACE; the disease is preeclampsia.