NEU1 and cardiac hypertrophy: Meanwhile, in experiments involving cardiomyocyte-specific NEU1 knockout and NEU1 overexpression, it was found that cardiomyocyte-specific NEU1 knockout significantly alleviates pathological myocardial hypertrophy in the aortic arch constriction (TAC) and isoproterenol (ISO) stimulation models [73], whereas NEU1 overexpression exacerbates TAC-induced pathological myocardial hypertrophy, which suggests that NEU1 critically drives cardiac hypertrophy.