SOX4, LGALS3, and SERPINE2 were strongly correlated with liver fibrosis grade and liver disease progression, with correlation coefficients (R) as high as 0.62 and 0.84 for SOX4 and 0.54 and 0.73 for LGALS3, respectively (Figure 6A,B). This evidence concerns the gene SERPINE2 and Hepatic fibrosis.