EDN1 and Hepatic fibrosis: The terminal differentiation marker Cd209b of LSECs was significantly downregulated in all three groups of liver fibrosis models [29], whereas the capillarization marker gene Cd34 and the Edn1 receptor Ednrb of LSECs were significantly upregulated in all three groups of liver fibrosis models (Supplementary Table S1) [30,31].