In most human cancers, endothelin activates the MAPK, NF-kB, β-catenin, PI3K/AKT, and Rho GTPase pathways, regulating the expression of genes essential for cell survival, proliferation, drug resistance, angiogenesis, osteogenesis, immune modulation, invasion, and metastasis [43]. The gene discussed is NFKB1; the disease is cancer.