BDNF and aceruloplasminemia: Interestingly, in the same study, the BDNF levels in the granule cell (GC) layer of the SCA6 mice were also decreased, and our exploration of a publicly available transcriptomic dataset from the cerebella of healthy humans and patients with ataxia telangiectasia (AT) [11] revealed that NTRK2 expression was reduced in the GCs of the AT cerebella, suggesting that GC dysfunction may also contribute to cerebellar ataxias.