Interestingly, in the same study, the BDNF levels in the granule cell (GC) layer of the SCA6 mice were also decreased, and our exploration of a publicly available transcriptomic dataset from the cerebella of healthy humans and patients with ataxia telangiectasia (AT) [11] revealed that NTRK2 expression was reduced in the GCs of the AT cerebella, suggesting that GC dysfunction may also contribute to cerebellar ataxias. This evidence concerns the gene NTRK2 and aceruloplasminemia.