RYR2 and hepatocellular carcinoma: Furthermore, in HCC tissues from the ICGC, we observed a similar pattern with the top 20 high-frequency mutation genes being TTN, TP53, CTNNB1, PCLO, MUC16, APO8, ALB, LRP1B, GSMD3, ARID1A, XIRP2 (8.1%), EYS, DST, ADGRV1, MUC19, ARID2, RYR2, ABCA13, HMCN1, and DNAH7 (Figure 1B).