We identified an HCC cell line (SNU475) carrying the XIRP2 mutation (I827V), as well as five HCC cell lines (HepG2, Hep3B, Huh7, Huh1, and SK-Hep1) with the XIRP2 wildtype, which were utilized in our experiments. The gene discussed is XIRP2; the disease is hepatocellular carcinoma.