A total of 15 high frequency mutation genes, including TP53, TTN, CTNNB1, MUC16, PCLO, APOB, ALB, LRP1B, GSMD3, ARID1A, XIRP2, ADGRV1, RYR2, ABCA13, and HMCN1, were identified as being overlapped in HCC tissues from both the TCGA and ICGC datasets (Figure 1C). The gene discussed is RYR2; the disease is hepatocellular carcinoma.