A total of 15 high frequency mutation genes, including TP53, TTN, CTNNB1, MUC16, PCLO, APOB, ALB, LRP1B, GSMD3, ARID1A, XIRP2, ADGRV1, RYR2, ABCA13, and HMCN1, were identified as being overlapped in HCC tissues from both the TCGA and ICGC datasets (Figure 1C). This evidence concerns the gene LRP1B and hepatocellular carcinoma.