Meanwhile, some amino acid sites in the VH region were mutated into S, for example, the frequencies of G8 (63/106, 59.4%), G28 (71/106, 67.0%), and G49 (57/106, 53.8%) in IGHV4-59 of AML-Igα mutated to S were higher than G8 (15/315, 4.8%), G28 (14/315, 4.4%), and G49 (12/315, 3.8%) of B-Igα in AML9 (Figure 5E). This evidence concerns the gene CD79A and acute myeloid leukemia.