Take AML 17 as an example, IGHV4-39/IGHD1-26/IGHJ5 in Igγ, IGHV3-7/IGHD1-26/IGHJ4 in Igμ, IGHV4-39/IGHD3-22/IGHJ4 in Igα, and IGHV4-34/IGHD2-15/IGHJ6 in Igδ were among the highest in usages in myeloblasts. Here, CD40LG is linked to acute myeloid leukemia.