For example, Igμ, Igα, and Igε in AML-Ig from AML3 tended to use IGHV4-59/IGHD3-16/IGHJ6 (141/1018, 13.8%), IGHV4-31/IGHD3-10/IGHJ3 (623/2680, 23.2%), and IGHV3-23/IGHD3-16/IGHJ6 (137/1058, 13.0%), respectively (Figure 6B, left). The gene discussed is IGHE; the disease is acute myeloid leukemia.