LPO represents an important marker of obesity-related inflammation and disease potential [4], and the increased concentration of LPO within exosomes has been shown to act as an endogenous activator of the Toll-like receptor 4 pathway to elicit an elevated pro-inflammatory response via the nuclear factor κB transcription factor [24]. This evidence concerns the gene TLR4 and obesity due to melanocortin 4 receptor deficiency.