Thus, astrocytoma and GBM are divided into IDH-mutated and wild-type IDH, oligodendrogliomas in IDH-mutated and tumors with 1p/19q co-deletion, and, finally, diffuse midline gliomas are defined by the histone H3K27M mutation [83,84,85]. This evidence concerns the gene IDH1 and astrocytoma (excluding glioblastoma).