Other biomarkers of considerable relevance in the early diagnosis of GBM are the mutated mRNA encoding the isocitrate dehydrogenase 1 (IDH1) enzyme and a group of miRNAs, among which are miR-21, which are present in glioma-derived EVs [180] and involved in the vascular proliferation of glioma. This evidence concerns the gene IDH1 and central nervous system cancer.