Through RNA sequencing, miRNA-21a was identified as a regulatory molecule, able to induce increased proliferation of neuronal stem cells (NSCs), by targeting the mRNAs encoding the SRY-box transcription factor 2 (SOX2), and the signal transducer and activator of transcription 3 (STAT3), thus contributing to the invasiveness of GBM. The gene discussed is STAT3; the disease is glioblastoma.