Most of these events are mediated by the ability of the tumor cells to produce large amounts of EVs that indeed contain extracellular proteins, among which are the extracellular matrix protein 1 (ECM-1) and collagen IV, as well as ECM-remodeling enzymes, among which are gelatinase MMP-2 (both in pro-enzymatic and active form), and the pro-MMP9 [105,106,107,108]. The gene discussed is ECM1; the disease is neoplasm.