The proteins CALR, RPSA, ACTB, KRT8, UAP56, SOD1, PSME1, PDIA3, ANXA1, CAH1, IDHC, PPIA and PPIB presented a differential expression when all stages of endometrial cancer were compared to complex atypical hyperplasia, with downregulation of SOD1 in all endometrial cancer samples and downregulation of CAH1 and PPIB only in stage IA samples [25]. This evidence concerns the gene PDIA3 and endometrial cancer.