Comparing high-risk endometrial cancer versus normal endometrium, eighteen proteins showed differential expression: PKM2, HSPA5, FH, PSMC5, VIM, ALDOC, VDAC2, HNRPD, GAPDH, and EEF2 with an increased expression, and PGK1, HSPA1B, CAH1, PRDX2, C3, TF, IGHA1, and ALB with a decreased expression. This evidence concerns the gene CYP21A2 and endometrial cancer.