CD274 and neoplasm: Joo et al. integrated SD-208 (a novel transforming growth factor-β (TGF-β) inhibitor that inhibits tumor proliferation and metastasis) and anti-PD-L1 (aPD-L1 Ab) (an immune checkpoint inhibitor that induces T cell-mediated tumor cell death) into soluble self-locking MNs, which can effectively treat melanoma (Figure 10e) [108].