CRP and Alzheimer disease: The landmark European Association for the Study of the Liver-Chronic Liver Failure Consortium Acute-on-Chronic Liver Failure in Cirrhosis study, that involved 1,343 European patients hospitalized for AD, provided the first evidence-based definition of ACLF and demonstrated that patients with ACLF have more severe bacterial infections and greater systemic inflammation, demonstrated by raised leucocytes and CRP (6).