Artemisinin dormancy phenomenon mayplay a role in recrudescence cases which may contribute to maintaining certainlevels of HRP2 detectable by especially ultrasensitive HRP2-based RDTs (20, 74).However, evidence for the possible influence of long-term parasitemia below theusual detection threshold on HRP2-RDT positivity is scarce. This evidence concerns the gene HDGFL2 and parasitic infectious disease.