PRNP and neuroblastoma: To investigate if prion-infected cells are resistant to IAV/WSN infection, we infected IAV/WSN at a multiplicity of infection (MOI) of 1.0 into N2aC24L1-3 cells, which are exogenous mouse PrPC-overexpressing, 22L scrapie prion persistently infected cloned mouse neuroblastoma N2aC24 cells, and prion-uninfected N2aC24 cells as a control (29).