NLRP3 and early-onset parkinsonism-intellectual disability syndrome: We then showed that, in prion-infected cells, the nuclear translocation of the transcription factor NF-κB was disturbed after IAV/WSN infection, therefore suppressing the gene expression of mitochondrial superoxide dismutase (SOD2), elevating mitochondrial reactive oxygen species (mtROS), and eventually activating the NLRP3 inflammasome.