These results indicate that prion-infected cells could accumulate PrP molecules in the cytosol, thereby the nuclear translocation of NF-κB was disturbed through the PrP cryptic nuclear translocation signal and eventually NLRP3 inflammasome was activated to protect from IAV/WSN infection, suggesting that PrPSc-prions might play a functional role in viral infections. The gene discussed is NLRP3; the disease is viral infectious disease.