In line with LOY detected by RNAseqCNV and WGS, differential gene expression (DEG) analysis showed a significant global downregulation of Y chromosome genes in HG-3 SF3B1 mutant cells (Fig. 5A), highlighting a critical role of SF3B1 mutation in driving LOY in CLL. The gene discussed is SF3B1; the disease is B-cell chronic lymphocytic leukemia.