In the HG-3 cell line, which contains the pre-existing del(13q) genetic lesion, we identified genetic deletions at chromosomal locations 17q25.1, 1p31.3, 1p36.21b, and 9q34.3 shared with CLL patient samples containing both SF3B1 mutation and del(13q) (Fig. 4E). The gene discussed is SF3B1; the disease is B-cell chronic lymphocytic leukemia.