Higher level of CNV events also appear to be associated with SF3B1 mutation in primary CLL patient samples with either del(13q) or del(17p), the two most common genetic lesions in CLL (Fig. 4D; refs. 16, 41, 52), suggesting that CNV changes are a general consequence of SF3B1 mutation. Here, SF3B1 is linked to B-cell chronic lymphocytic leukemia.