FASN, the sole human lipogenic enzyme capable of de novo fatty acid synthesis, catalyzes the endogenous synthesis of fatty acids.29 Here, we found that, in ESCC cells, suppressing of FASN or FLOT1 almost completely attenuated intracellular TG and PA accumulation induced by recombinant FadAL or Fp infection. Here, FLOT1 is linked to esophageal squamous cell carcinoma.