The largest mediator of the causal effect from education to DKD was BMI (40.2%; 95% CI 26.6, 53.7%), followed by WHR (39.2%; 95% CI 21.0, 57.5%), T2D (31.2%; 95% CI 18.7, 43.7%), fasting insulin (20.6%; 95% CI 1.6, 39.6%), SBP (9.3%; 95% CI 5.0, 13.6%), fasting glucose (8.0%; 95% CI 0.6, 15.4%) and DBP (2.7%; 95% CI 0.4, 5.1%) (Figure 3). The gene discussed is INS; the disease is type 2 diabetes mellitus.